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- biologically important compounds such as hormones like melatonin and the neurotransmitter serotonin (5-hydroxytryptamine). Many psychoactive tryptamines have10 KB (461 words) - 23:05, 21 April 2024
- chemical compounds that act on cannabinoid receptors on cells that alter neurotransmitter functioning in the brain. These receptor proteins include the endocannabinoids27 KB (3,598 words) - 22:59, 21 April 2024
- Main Page (section Please don't crawl the wiki. Use our API instead.PsychonautWiki ❤️ Developers. Please report any obstacles.)Adrenaline ⋅ Dopamine ⋅ GABA ⋅ Glutamate ⋅ Hormone ⋅ Melatonin ⋅ Neuron ⋅ Neurotransmitter ⋅ Noradrenaline ⋅ Receptor ⋅ Serotonin ⋅ Serotonin syndrome ⋅ Substance21 KB (1,004 words) - 23:38, 13 May 2024
- info - Home https://psychonautwiki.org/wiki/File:Behandeling-4-fa-intoxicatie.pdf https://psychonautwiki.org/wiki/File:4-FA%20risicobeoordeling%20(2016)21 KB (3,439 words) - 15:42, 30 July 2022
- this substantion. It can get up to around 2.5-3 points on the psychonaut wiki scale. (click Traces above to read more) Transformations - This effect occurs41 KB (5,610 words) - 19:01, 7 April 2024
- as being a normal constituent of human metabolism and an endogenous neurotransmitter in certain rodents. Its presence is also known to be widespread throughout58 KB (7,681 words) - 22:15, 14 May 2024
- plays a role, although to a much lesser degree. This sudden increase in neurotransmitter concentration in the brain is thought to be responsible for the high23 KB (3,267 words) - 23:45, 21 April 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Cognitive fatigue Thought11 KB (1,055 words) - 02:52, 12 May 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Appetite suppression41 KB (5,798 words) - 13:29, 16 April 2024
- benzodiazepine receptor site and magnifying the efficiency and effects of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors. As this22 KB (2,595 words) - 13:26, 16 April 2024
- Molecular structure (section Neurotransmitters)In order to maintain consistency across the wiki, images of molecular structures should be produced in a standardized format rather than obtained from19 KB (857 words) - 09:55, 15 September 2022
- Antidepressants are thought to work by increasing levels of certain neurotransmitters, such as dopamine, serotonin, and/or norepinephrine in certain regions9 KB (1,069 words) - 21:47, 13 May 2024
- signals to pass, the NMDA receptor must be open. To remain open, the neurotransmitters known as glutamate and glycine must bind to the NMDA receptor. An NMDA12 KB (1,097 words) - 02:41, 12 May 2024
- means that they structurally mimic the endogenous neurotransmitter known as serotonin, the neurotransmitter that regulates higher-level brain functions such31 KB (3,363 words) - 22:58, 21 April 2024
- altering the availability of the brain's supply of neurochemicals (i.e. neurotransmitters, enzymes, and hormones), by improving the brain's oxygen supply, or6 KB (658 words) - 23:00, 21 April 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue21 KB (3,467 words) - 16:14, 30 July 2022
- GABA-A receptor complex, magnifying the efficicacy and effects of the neurotransmitter gamma aminobutyric acid (GABA) by increasing its ability to bind more30 KB (3,506 words) - 14:22, 16 April 2024
- benzodiazepine receptor site and magnifying the efficiency and effects of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors. As this22 KB (2,689 words) - 20:55, 7 April 2024
- A1 and A2A receptors. During waking periods, the brain levels of the neurotransmitter adenosine steadily increase and trigger fatigue and sleepiness. The14 KB (1,908 words) - 08:31, 1 November 2023
- Adrenaline (category Neurotransmitter)Adrenaline (also known as epinephrine) is a hormone and neurotransmitter. It is primarily produced in the adrenal glands and certain neurons in humans5 KB (628 words) - 23:12, 21 April 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Appetite suppression33 KB (4,870 words) - 14:34, 16 April 2024
- often referred to as a "comedown" and is thought to occur because of neurotransmitter depletion. Although, it has been more and more commonly recognized85 KB (10,499 words) - 14:24, 16 April 2024
- GHB (category Neurotransmitter)acid and GHB) is a depressant substance. It is found naturally as a neurotransmitter and is also a precursor to GABA, glutamate, and glycine in certain35 KB (4,460 words) - 13:32, 16 April 2024
- by magnifying the efficiency and effects of the principal inhibitory neurotransmitter gamma-aminobutyric acid (GABA) by binding to and acting on its receptors28 KB (3,429 words) - 03:46, 9 May 2024
- doses, as agonists of GABAA receptors. GABA is the principal inhibitory neurotransmitter in the mammalian central nervous system (CNS). Barbiturates bind to16 KB (1,815 words) - 09:25, 14 January 2023
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue31 KB (4,254 words) - 15:15, 6 May 2024
- 2C-T-2 (category PsychonautWiki articles needing factual verification from October 2020)that 2C-T-2 is more likely to induce serotonin syndrome or general neurotransmitter overload (especially at high dosages) than other serotonergic psychedelics22 KB (2,627 words) - 23:08, 29 May 2021
- homeostasis. Among the neurotransmitters which are suppressed/inhibited however, these include: Glutamate: By making this excitatory neurotransmitter less effective95 KB (11,688 words) - 02:47, 12 May 2024
- unknown. They are believed to increase the extracellular level of the neurotransmitter serotonin, eventually leading to improved mood.[citation needed][clarification15 KB (1,687 words) - 18:59, 22 November 2023
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue29 KB (3,963 words) - 14:23, 16 April 2024
- is often referred to as a comedown or “crash” and occurs because of neurotransmitter depletion. Many users report however that the severity of the “crash”47 KB (6,322 words) - 08:08, 3 May 2024
- Haurand, M., Wilffert, B. (November 1996). "Influence of tramadol on neurotransmitter systems of the rat brain". Arzneimittel-Forschung. 46 (11): 1029–103622 KB (3,211 words) - 19:11, 7 April 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue13 KB (1,917 words) - 18:16, 30 April 2024
- Phenibut acts as a receptor agonist for GABA, the major inhibitory neurotransmitter in the brain. It is chemically related to baclofen, pregabalin, and22 KB (2,703 words) - 18:36, 26 August 2023
- Phenethylamine (compound) (category Neurotransmitter)functions as a monoaminergic neuromodulator and, to a lesser extent, a neurotransmitter in the human central nervous system. In addition to its presence in7 KB (919 words) - 17:25, 24 November 2023
- inhibiting its endogenous function of destroying amine functions of neurotransmitters and externally administered centrally active drugs. This has the effect13 KB (1,772 words) - 02:21, 24 September 2023
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue19 KB (2,841 words) - 14:21, 16 April 2024
- and GABOB. It is a derivative of the naturally occurring inhibitory neurotransmitter γ-aminobutyric acid (GABA), with an addition of a phenyl ring that12 KB (1,795 words) - 20:04, 18 November 2023
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue15 KB (2,265 words) - 06:42, 8 September 2023
- Its mechanism of action is to increase the effects of the inhibitory neurotransmitter GABA. Diazepam was patented in 1955 by the pharmaceutical company Hoffman-La34 KB (4,165 words) - 14:05, 16 April 2024
- Scientific information (section Neurotransmitters)syndrome SSRI SNRI Synthetic cannabinoids Vagus nerve Hormone Neuron Neurotransmitter Monoamine Receptor Synapse Blood–brain barrier Serotonin Dopamine Glutamate599 bytes (162 words) - 23:00, 21 April 2024
- is thought to emerge from the close chemical similarities with the neurotransmitter serotonin, which enables it to interact with a range of serotonin receptor40 KB (4,715 words) - 16:45, 25 January 2024
- elusive. Additional mechanisms of action such as reuptake inhibition of neurotransmitters such as serotonin, noradrenaline and dopamine are also thought to be16 KB (2,273 words) - 19:54, 7 April 2024
- substance of the gabapentinoid class. It is a structural analog of the neurotransmitter GABA and acts by inhibiting certain calcium channels in the brain,23 KB (2,828 words) - 23:50, 21 April 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. The comedown produced by lisdexamfetamine, depending on23 KB (3,617 words) - 09:16, 17 April 2024
- A1 and A2A receptors. During waking periods, the brain levels of the neurotransmitter adenosine steadily increase and trigger fatigue and sleepiness. The29 KB (3,603 words) - 00:00, 10 May 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue12 KB (1,928 words) - 23:42, 21 April 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue18 KB (2,590 words) - 21:20, 30 April 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Appetite suppression26 KB (4,015 words) - 23:44, 21 April 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue19 KB (3,317 words) - 15:23, 30 July 2022
- indicate that 2C-T is more likely to induce serotonin syndrome or general neurotransmitter overload (especially at high dosages) than other serotonergic psychedelics13 KB (1,528 words) - 23:08, 29 May 2021
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue13 KB (2,233 words) - 00:32, 31 December 2022
- Eszopiclone is thought to increase the normal neurotransmission of the neurotransmitter GABA in the central nervous system in a similar yet distinct way to9 KB (1,257 words) - 18:31, 30 April 2024
- 1007/978-90-481-2448-0_27. ISBN 9789048124480. Research Chemicals - TripSit wiki Erowid 2C-B-Fly Vault: Death Reports 2009 Griffin, D., Second Victim Dies19 KB (2,209 words) - 23:08, 21 April 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue18 KB (2,561 words) - 14:02, 16 April 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. More specifically, some users have observed that the comedown20 KB (2,747 words) - 00:19, 1 August 2022
- dextrorotary enantiomer. Theanine is structurally similar to the excitatory neurotransmitter glutamate, and in accordance, binds to glutamate receptors, though15 KB (1,935 words) - 23:24, 21 April 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue14 KB (2,336 words) - 23:43, 21 April 2024
- norepinephrine receptors on the receiving neurons. This sudden increase in neurotransmitter concentration in the brain is thought to be responsible for the high11 KB (1,751 words) - 20:42, 12 September 2022
- available to purchase as a dietary supplement. Responsible use Oneirogen Neurotransmitter Hormone Tryptamine Melatonin (Wikipedia) Melatonin as a medication15 KB (1,896 words) - 23:12, 21 April 2024
- Choline is a chemical substance which serves as a precursor to the neurotransmitter acetylcholine in the brain. Choline is an essential nutrient in humans15 KB (1,961 words) - 23:23, 21 April 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue16 KB (2,465 words) - 15:45, 9 May 2024
- (PsychonautWiki) | https://psychonautwiki.org/wiki/3-MeO-PCP#Toxicity_and_harm_potential PCP Psychosis (PsychonautWiki) | https://psychonautwiki.org/wiki/3-M18 KB (2,543 words) - 21:36, 21 July 2022
- at the alpha carbon. Piracetam shares structural similarity to the neurotransmitter GABA, its pyrrolidine core is the cyclic counterpart of GABA and could12 KB (1,475 words) - 00:39, 15 April 2023
- effects, ayahuasca is more likely to induce serotonin syndrome or general neurotransmitter overload (especially at high dosages) than other serotonergic psychedelics33 KB (3,884 words) - 07:33, 16 November 2023
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue11 KB (1,914 words) - 23:46, 21 April 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue19 KB (2,684 words) - 18:04, 30 July 2022
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Appetite suppression20 KB (2,813 words) - 21:23, 25 October 2023
- that 2C-T-21 is more likely to induce serotonin syndrome or general neurotransmitter overload (especially at high dosages) than other serotonergic psychedelics18 KB (2,002 words) - 06:06, 12 August 2022
- elusive. Additional mechanisms of action such as reuptake inhibition of neurotransmitters such as serotonin, noradrenaline and dopamine are also thought to be26 KB (3,619 words) - 19:56, 7 April 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue17 KB (2,757 words) - 17:49, 30 July 2022
- that 2C-T-7 is more likely to induce serotonin syndrome or general neurotransmitter overload (especially at high dosages) than other serotonergic psychedelics22 KB (2,709 words) - 23:09, 29 May 2021
- its receptor sites and magnifying the efficiency and effects of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors. As this12 KB (1,829 words) - 23:50, 21 April 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. It is significantly less intensive and uncomfortable with14 KB (2,109 words) - 23:22, 21 April 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue17 KB (2,584 words) - 12:23, 5 April 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Appetite suppression25 KB (3,654 words) - 23:46, 21 April 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety - Mild at low-moderate24 KB (3,701 words) - 23:42, 21 April 2024
- acting as an inhibitory ligand, inhibiting the release of excitatory neurotransmitters. Similarly to phenibut (β-phenyl-GABA), as well as pregabalin (β-isobutyl-GABA)16 KB (1,962 words) - 02:04, 19 March 2024
- this may have been a factor in producing chemicals similar enough to neurotransmitters so as to activate receptor sites. For example many psychoactive chemicals70 KB (630 words) - 04:11, 16 May 2024
- thought to act immediately through the regulation of monoaminergic neurotransmitters (such as serotonin, dopamine, or noradrenaline.) Rather, it is theorized20 KB (2,399 words) - 00:17, 6 May 2024
- effects principally as an NMDA receptor antagonist, although other neurotransmitter systems may be involved.[citation needed] NMDA receptors (a subtype16 KB (2,133 words) - 17:21, 17 March 2024
- benzodiazepine receptor site and magnifying the efficiency and effects of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors. Alprazolam25 KB (3,914 words) - 14:31, 16 April 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue17 KB (3,024 words) - 17:25, 18 January 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue18 KB (2,647 words) - 23:46, 21 April 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue17 KB (2,532 words) - 22:27, 31 July 2022
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue15 KB (2,726 words) - 11:39, 17 February 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue17 KB (2,560 words) - 07:40, 12 October 2023
- theacrine is believed to have similar effects on most of the other major neurotransmitters, including dopamine, acetylcholine, serotonin, and, in high doses,10 KB (1,245 words) - 19:38, 30 April 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue17 KB (2,503 words) - 00:26, 6 May 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue25 KB (3,455 words) - 23:45, 21 April 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. It has been reported that this crash is usually not considered21 KB (3,212 words) - 09:58, 30 May 2023
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue8 KB (961 words) - 23:45, 21 April 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. The comedown of MDA is generally considered harsher compared31 KB (4,379 words) - 12:23, 6 May 2024
- it activates the receptor for GABA, the brain's principle inhibitory neurotransmitter. As an agonist, muscimol binds to the same site on the GABAA receptor16 KB (1,938 words) - 23:10, 21 April 2024
- α-PVP does not act as a transporter substrate, i.e. it does not cause neurotransmitter release. It is a more potent inhibitor of DAT and NET than the classical24 KB (3,456 words) - 00:08, 3 November 2023
- Its mechanism of action is to increase the effects of the inhibitory neurotransmitter GABA. Chlordiazepoxide is notable among benzodiazepines for having15 KB (1,705 words) - 18:08, 14 January 2024
- drugs, characterized by their ability to enhance the effect of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain. It is chemically described2 KB (240 words) - 21:42, 5 May 2024
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue19 KB (2,776 words) - 00:39, 1 August 2022
- peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue9 KB (1,564 words) - 23:45, 21 April 2024
- literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of25 KB (2,825 words) - 16:14, 28 November 2022