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  • biologically important compounds such as hormones like melatonin and the neurotransmitter serotonin (5-hydroxytryptamine). Many psychoactive tryptamines have
    10 KB (461 words) - 23:05, 21 April 2024
  • chemical compounds that act on cannabinoid receptors on cells that alter neurotransmitter functioning in the brain. These receptor proteins include the endocannabinoids
    27 KB (3,598 words) - 22:59, 21 April 2024
  • Adrenaline ⋅ Dopamine ⋅ GABA ⋅ Glutamate ⋅ Hormone ⋅ Melatonin ⋅ Neuron ⋅ Neurotransmitter ⋅ Noradrenaline ⋅ Receptor ⋅ Serotonin ⋅ Serotonin syndrome ⋅ Substance
    21 KB (1,004 words) - 23:38, 13 May 2024
  • info - Home  https://psychonautwiki.org/wiki/File:Behandeling-4-fa-intoxicatie.pdf https://psychonautwiki.org/wiki/File:4-FA%20risicobeoordeling%20(2016)
    21 KB (3,439 words) - 15:42, 30 July 2022
  • this substantion. It can get up to around 2.5-3 points on the psychonaut wiki scale. (click Traces above to read more) Transformations - This effect occurs
    41 KB (5,610 words) - 19:01, 7 April 2024
  • as being a normal constituent of human metabolism and an endogenous neurotransmitter in certain rodents. Its presence is also known to be widespread throughout
    58 KB (7,681 words) - 22:15, 14 May 2024
  • plays a role, although to a much lesser degree. This sudden increase in neurotransmitter concentration in the brain is thought to be responsible for the high
    23 KB (3,267 words) - 23:45, 21 April 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Cognitive fatigue Thought
    11 KB (1,055 words) - 02:52, 12 May 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Appetite suppression
    41 KB (5,798 words) - 13:29, 16 April 2024
  • benzodiazepine receptor site and magnifying the efficiency and effects of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors. As this
    22 KB (2,595 words) - 13:26, 16 April 2024
  • In order to maintain consistency across the wiki, images of molecular structures should be produced in a standardized format rather than obtained from
    19 KB (857 words) - 09:55, 15 September 2022
  • Antidepressants are thought to work by increasing levels of certain neurotransmitters, such as dopamine, serotonin, and/or norepinephrine in certain regions
    9 KB (1,069 words) - 21:47, 13 May 2024
  • signals to pass, the NMDA receptor must be open. To remain open, the neurotransmitters known as glutamate and glycine must bind to the NMDA receptor. An NMDA
    12 KB (1,097 words) - 02:41, 12 May 2024
  • means that they structurally mimic the endogenous neurotransmitter known as serotonin, the neurotransmitter that regulates higher-level brain functions such
    31 KB (3,363 words) - 22:58, 21 April 2024
  • altering the availability of the brain's supply of neurochemicals (i.e. neurotransmitters, enzymes, and hormones), by improving the brain's oxygen supply, or
    6 KB (658 words) - 23:00, 21 April 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
    21 KB (3,467 words) - 16:14, 30 July 2022
  • GABA-A receptor complex, magnifying the efficicacy and effects of the neurotransmitter gamma aminobutyric acid (GABA) by increasing its ability to bind more
    30 KB (3,506 words) - 14:22, 16 April 2024
  • benzodiazepine receptor site and magnifying the efficiency and effects of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors. As this
    22 KB (2,689 words) - 20:55, 7 April 2024
  • A1 and A2A receptors. During waking periods, the brain levels of the neurotransmitter adenosine steadily increase and trigger fatigue and sleepiness. The
    14 KB (1,908 words) - 08:31, 1 November 2023
  • Adrenaline (category Neurotransmitter)
    Adrenaline (also known as epinephrine) is a hormone and neurotransmitter. It is primarily produced in the adrenal glands and certain neurons in humans
    5 KB (628 words) - 23:12, 21 April 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Appetite suppression
    33 KB (4,870 words) - 14:34, 16 April 2024
  • often referred to as a "comedown" and is thought to occur because of neurotransmitter depletion. Although, it has been more and more commonly recognized
    85 KB (10,499 words) - 14:24, 16 April 2024
  • GHB (category Neurotransmitter)
    acid and GHB) is a depressant substance. It is found naturally as a neurotransmitter and is also a precursor to GABA, glutamate, and glycine in certain
    35 KB (4,460 words) - 13:32, 16 April 2024
  • by magnifying the efficiency and effects of the principal inhibitory neurotransmitter gamma-aminobutyric acid (GABA) by binding to and acting on its receptors
    28 KB (3,429 words) - 03:46, 9 May 2024
  • doses, as agonists of GABAA receptors. GABA is the principal inhibitory neurotransmitter in the mammalian central nervous system (CNS). Barbiturates bind to
    16 KB (1,815 words) - 09:25, 14 January 2023
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
    31 KB (4,254 words) - 15:15, 6 May 2024
  • 2C-T-2 (category PsychonautWiki articles needing factual verification from October 2020)
    that 2C-T-2 is more likely to induce serotonin syndrome or general neurotransmitter overload (especially at high dosages) than other serotonergic psychedelics
    22 KB (2,627 words) - 23:08, 29 May 2021
  • homeostasis. Among the neurotransmitters which are suppressed/inhibited however, these include: Glutamate: By making this excitatory neurotransmitter less effective
    95 KB (11,688 words) - 02:47, 12 May 2024
  • unknown. They are believed to increase the extracellular level of the neurotransmitter serotonin, eventually leading to improved mood.[citation needed][clarification
    15 KB (1,687 words) - 18:59, 22 November 2023
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
    29 KB (3,963 words) - 14:23, 16 April 2024
  • is often referred to as a comedown or “crash” and occurs because of neurotransmitter depletion. Many users report however that the severity of the “crash”
    47 KB (6,322 words) - 08:08, 3 May 2024
  • Haurand, M., Wilffert, B. (November 1996). "Influence of tramadol on neurotransmitter systems of the rat brain". Arzneimittel-Forschung. 46 (11): 1029–1036
    22 KB (3,211 words) - 19:11, 7 April 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
    13 KB (1,917 words) - 18:16, 30 April 2024
  • Phenibut acts as a receptor agonist for GABA, the major inhibitory neurotransmitter in the brain. It is chemically related to baclofen, pregabalin, and
    22 KB (2,703 words) - 18:36, 26 August 2023
  • Phenethylamine (compound) (category Neurotransmitter)
    functions as a monoaminergic neuromodulator and, to a lesser extent, a neurotransmitter in the human central nervous system. In addition to its presence in
    7 KB (919 words) - 17:25, 24 November 2023
  • inhibiting its endogenous function of destroying amine functions of neurotransmitters and externally administered centrally active drugs. This has the effect
    13 KB (1,772 words) - 02:21, 24 September 2023
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
    19 KB (2,841 words) - 14:21, 16 April 2024
  • and GABOB. It is a derivative of the naturally occurring inhibitory neurotransmitter γ-aminobutyric acid (GABA), with an addition of a phenyl ring that
    12 KB (1,795 words) - 20:04, 18 November 2023
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
    15 KB (2,265 words) - 06:42, 8 September 2023
  • Its mechanism of action is to increase the effects of the inhibitory neurotransmitter GABA. Diazepam was patented in 1955 by the pharmaceutical company Hoffman-La
    34 KB (4,165 words) - 14:05, 16 April 2024
  • syndrome SSRI SNRI Synthetic cannabinoids Vagus nerve Hormone Neuron Neurotransmitter Monoamine Receptor Synapse Blood–brain barrier Serotonin Dopamine Glutamate
    599 bytes (162 words) - 23:00, 21 April 2024
  • is thought to emerge from the close chemical similarities with the neurotransmitter serotonin, which enables it to interact with a range of serotonin receptor
    40 KB (4,715 words) - 16:45, 25 January 2024
  • elusive. Additional mechanisms of action such as reuptake inhibition of neurotransmitters such as serotonin, noradrenaline and dopamine are also thought to be
    16 KB (2,273 words) - 19:54, 7 April 2024
  • substance of the gabapentinoid class. It is a structural analog of the neurotransmitter GABA and acts by inhibiting certain calcium channels in the brain,
    23 KB (2,828 words) - 23:50, 21 April 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. The comedown produced by lisdexamfetamine, depending on
    23 KB (3,617 words) - 09:16, 17 April 2024
  • A1 and A2A receptors. During waking periods, the brain levels of the neurotransmitter adenosine steadily increase and trigger fatigue and sleepiness. The
    29 KB (3,603 words) - 00:00, 10 May 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
    12 KB (1,928 words) - 23:42, 21 April 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
    18 KB (2,590 words) - 21:20, 30 April 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Appetite suppression
    26 KB (4,015 words) - 23:44, 21 April 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
    19 KB (3,317 words) - 15:23, 30 July 2022
  • indicate that 2C-T is more likely to induce serotonin syndrome or general neurotransmitter overload (especially at high dosages) than other serotonergic psychedelics
    13 KB (1,528 words) - 23:08, 29 May 2021
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
    13 KB (2,233 words) - 00:32, 31 December 2022
  • Eszopiclone is thought to increase the normal neurotransmission of the neurotransmitter GABA in the central nervous system in a similar yet distinct way to
    9 KB (1,257 words) - 18:31, 30 April 2024
  • 1007/978-90-481-2448-0_27. ISBN 9789048124480.  Research Chemicals - TripSit wiki  Erowid 2C-B-Fly Vault: Death Reports 2009  Griffin, D., Second Victim Dies
    19 KB (2,209 words) - 23:08, 21 April 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
    18 KB (2,561 words) - 14:02, 16 April 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. More specifically, some users have observed that the comedown
    20 KB (2,747 words) - 00:19, 1 August 2022
  • dextrorotary enantiomer. Theanine is structurally similar to the excitatory neurotransmitter glutamate, and in accordance, binds to glutamate receptors, though
    15 KB (1,935 words) - 23:24, 21 April 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
    14 KB (2,336 words) - 23:43, 21 April 2024
  • norepinephrine receptors on the receiving neurons. This sudden increase in neurotransmitter concentration in the brain is thought to be responsible for the high
    11 KB (1,751 words) - 20:42, 12 September 2022
  • available to purchase as a dietary supplement. Responsible use Oneirogen Neurotransmitter Hormone Tryptamine Melatonin (Wikipedia) Melatonin as a medication
    15 KB (1,896 words) - 23:12, 21 April 2024
  • Choline is a chemical substance which serves as a precursor to the neurotransmitter acetylcholine in the brain. Choline is an essential nutrient in humans
    15 KB (1,961 words) - 23:23, 21 April 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
    16 KB (2,465 words) - 15:45, 9 May 2024
  • (PsychonautWiki) | https://psychonautwiki.org/wiki/3-MeO-PCP#Toxicity_and_harm_potential PCP Psychosis (PsychonautWiki) | https://psychonautwiki.org/wiki/3-M
    18 KB (2,543 words) - 21:36, 21 July 2022
  • at the alpha carbon. Piracetam shares structural similarity to the neurotransmitter GABA, its pyrrolidine core is the cyclic counterpart of GABA and could
    12 KB (1,475 words) - 00:39, 15 April 2023
  • effects, ayahuasca is more likely to induce serotonin syndrome or general neurotransmitter overload (especially at high dosages) than other serotonergic psychedelics
    33 KB (3,884 words) - 07:33, 16 November 2023
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
    11 KB (1,914 words) - 23:46, 21 April 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
    19 KB (2,684 words) - 18:04, 30 July 2022
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Appetite suppression
    20 KB (2,813 words) - 21:23, 25 October 2023
  • that 2C-T-21 is more likely to induce serotonin syndrome or general neurotransmitter overload (especially at high dosages) than other serotonergic psychedelics
    18 KB (2,002 words) - 06:06, 12 August 2022
  • elusive. Additional mechanisms of action such as reuptake inhibition of neurotransmitters such as serotonin, noradrenaline and dopamine are also thought to be
    26 KB (3,619 words) - 19:56, 7 April 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
    17 KB (2,757 words) - 17:49, 30 July 2022
  • that 2C-T-7 is more likely to induce serotonin syndrome or general neurotransmitter overload (especially at high dosages) than other serotonergic psychedelics
    22 KB (2,709 words) - 23:09, 29 May 2021
  • its receptor sites and magnifying the efficiency and effects of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors. As this
    12 KB (1,829 words) - 23:50, 21 April 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. It is significantly less intensive and uncomfortable with
    14 KB (2,109 words) - 23:22, 21 April 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
    17 KB (2,584 words) - 12:23, 5 April 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Appetite suppression
    25 KB (3,654 words) - 23:46, 21 April 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety - Mild at low-moderate
    24 KB (3,701 words) - 23:42, 21 April 2024
  • acting as an inhibitory ligand, inhibiting the release of excitatory neurotransmitters. Similarly to phenibut (β-phenyl-GABA), as well as pregabalin (β-isobutyl-GABA)
    16 KB (1,962 words) - 02:04, 19 March 2024
  • this may have been a factor in producing chemicals similar enough to neurotransmitters so as to activate receptor sites. For example many psychoactive chemicals
    70 KB (630 words) - 04:11, 16 May 2024
  • thought to act immediately through the regulation of monoaminergic neurotransmitters (such as serotonin, dopamine, or noradrenaline.) Rather, it is theorized
    20 KB (2,399 words) - 00:17, 6 May 2024
  • effects principally as an NMDA receptor antagonist, although other neurotransmitter systems may be involved.[citation needed] NMDA receptors (a subtype
    16 KB (2,133 words) - 17:21, 17 March 2024
  • benzodiazepine receptor site and magnifying the efficiency and effects of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors. Alprazolam
    25 KB (3,914 words) - 14:31, 16 April 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
    17 KB (3,024 words) - 17:25, 18 January 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
    18 KB (2,647 words) - 23:46, 21 April 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
    17 KB (2,532 words) - 22:27, 31 July 2022
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
    15 KB (2,726 words) - 11:39, 17 February 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
    17 KB (2,560 words) - 07:40, 12 October 2023
  • theacrine is believed to have similar effects on most of the other major neurotransmitters, including dopamine, acetylcholine, serotonin, and, in high doses,
    10 KB (1,245 words) - 19:38, 30 April 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
    17 KB (2,503 words) - 00:26, 6 May 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
    25 KB (3,455 words) - 23:45, 21 April 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. It has been reported that this crash is usually not considered
    21 KB (3,212 words) - 09:58, 30 May 2023
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
    8 KB (961 words) - 23:45, 21 April 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. The comedown of MDA is generally considered harsher compared
    31 KB (4,379 words) - 12:23, 6 May 2024
  • it activates the receptor for GABA, the brain's principle inhibitory neurotransmitter. As an agonist, muscimol binds to the same site on the GABAA receptor
    16 KB (1,938 words) - 23:10, 21 April 2024
  • α-PVP does not act as a transporter substrate, i.e. it does not cause neurotransmitter release. It is a more potent inhibitor of DAT and NET than the classical
    24 KB (3,456 words) - 00:08, 3 November 2023
  • Its mechanism of action is to increase the effects of the inhibitory neurotransmitter GABA. Chlordiazepoxide is notable among benzodiazepines for having
    15 KB (1,705 words) - 18:08, 14 January 2024
  • drugs, characterized by their ability to enhance the effect of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain. It is chemically described
    2 KB (240 words) - 21:42, 5 May 2024
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
    19 KB (2,776 words) - 00:39, 1 August 2022
  • peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
    9 KB (1,564 words) - 23:45, 21 April 2024
  • literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of
    25 KB (2,825 words) - 16:14, 28 November 2022

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