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• Molecular structure (section Neurotransmitters)
  In order to maintain consistency across the wiki, images of molecular structures should be produced in a standardized format rather than obtained from
  19 KB (857 words) - 09:55, 15 September 2022
• Methamphetamine
  lipid solubility. It produces its effects by increasing levels of the neurotransmitters serotonin, dopamine, and norepinephrine in the brain. Methamphetamine
  41 KB (5,798 words) - 13:29, 16 April 2024
• Naturally occurring sources
  this may have been a factor in producing chemicals similar enough to neurotransmitters so as to activate receptor sites. For example many psychoactive chemicals
  70 KB (630 words) - 04:11, 16 May 2024
• Amphetamine
  bupropion. The mechanism of action involves promoting release of the neurotransmitters dopamine and norepinephrine. It was first synthesized in 1887, but
  41 KB (5,610 words) - 19:01, 7 April 2024
• Research chemicals
  substance which act as a releasing agent or reuptake inhibitor of neurotransmitters such as serotonin and dopamine. DOC - There is one reported death from
  19 KB (2,209 words) - 23:08, 21 April 2024
• 6-APB
  fenfluramine. The monoamine neurotransmitters known as serotonin, dopamine and noradrenaline are the global neurotransmitters that modulate the brain's ability
  33 KB (4,870 words) - 14:34, 16 April 2024
• 4-FA
  info - Home  https://psychonautwiki.org/wiki/File:Behandeling-4-fa-intoxicatie.pdf https://psychonautwiki.org/wiki/File:4-FA%20risicobeoordeling%20(2016)
  21 KB (3,439 words) - 15:42, 30 July 2022
• PCE
  (PsychonautWiki) | https://psychonautwiki.org/wiki/3-MeO-PCP#Toxicity_and_harm_potential PCP Psychosis (PsychonautWiki) | https://psychonautwiki.org/wiki/3-M
  18 KB (2,543 words) - 21:36, 21 July 2022
• MDMA
  acts primarily as a releasing agent of the three principal monoamine neurotransmitters serotonin, norepinephrine, and dopamine through its action at trace
  85 KB (10,499 words) - 14:24, 16 April 2024
• MDPV
  dopamine results in higher concentrations of the two catecholamine neurotransmitters in the synaptic cleft, or gap between neurons. The result of this inhibition
  23 KB (3,267 words) - 23:45, 21 April 2024
• Stimulants
  the most prominent of which are increasing concentrations of the neurotransmitters dopamine and norepinephrine by either promoting release (e.g. amphetamine
  11 KB (1,055 words) - 02:52, 12 May 2024
• Antidepressants
  Antidepressants are thought to work by increasing levels of certain neurotransmitters, such as dopamine, serotonin, and/or norepinephrine in certain regions
  9 KB (1,069 words) - 21:47, 13 May 2024
• 4-FMA
  effectively boosts the levels of the norepinephrine, dopamine, and serotonin neurotransmitters in higher doses in the brain by binding to and partially blocking the
  21 KB (3,467 words) - 16:14, 30 July 2022
• Dissociatives
  signals to pass, the NMDA receptor must be open. To remain open, the neurotransmitters known as glutamate and glycine must bind to the NMDA receptor. An NMDA
  12 KB (1,097 words) - 02:41, 12 May 2024
• Psychedelic
  means that they structurally mimic the endogenous neurotransmitter known as serotonin, the neurotransmitter that regulates higher-level brain functions such
  31 KB (3,363 words) - 22:58, 21 April 2024
• Nootropic
  altering the availability of the brain's supply of neurochemicals (i.e. neurotransmitters, enzymes, and hormones), by improving the brain's oxygen supply, or
  6 KB (658 words) - 23:00, 21 April 2024
• Substituted tryptamines
  on January 11, 2020. Retrieved January 11, 2020.  https://en.wikipedia.org/wiki/List_of_psychedelic_drugs
  10 KB (461 words) - 23:05, 21 April 2024
• Adrenaline (category Neurotransmitter)
  attached to an ethane chain. This monoamine chain can be found in many neurotransmitters, including histamine, dopamine, serotonin and noradrenaline. It is
  5 KB (628 words) - 23:12, 21 April 2024
• GHB (category Neurotransmitter)
  acid and GHB) is a depressant substance. It is found naturally as a neurotransmitter and is also a precursor to GABA, glutamate, and glycine in certain
  35 KB (4,460 words) - 13:32, 16 April 2024
• Benzodiazepines
  by magnifying the efficiency and effects of the principal inhibitory neurotransmitter gamma-aminobutyric acid (GABA) by binding to and acting on its receptors
  28 KB (3,429 words) - 03:46, 9 May 2024
• Barbiturates
  At higher concentration, they inhibit the Ca2+-dependent release of neurotransmitters such as glutamate via an effect on P/Q-type voltage-dependent calcium
  16 KB (1,815 words) - 09:25, 14 January 2023
• Methylphenidate
  The mechanism of action involves increasing concentrations of the neurotransmitters dopamine and norepinephrine. It was first synthesized in 1944 and was
  31 KB (4,254 words) - 15:15, 6 May 2024
• Cannabinoid
  a comprehensive list of known synthetic cannabinoid derivatives, /r/Drugs/wiki has published a respectable directory of names and links to further information
  27 KB (3,598 words) - 22:59, 21 April 2024
• 2C-T-2 (category PsychonautWiki articles needing factual verification from October 2020)
  MAOIs, stimulants and certain substances which promotes the release of neurotransmitters such as serotonin or dopamine. These substances include but are not
  22 KB (2,627 words) - 23:08, 29 May 2021
• Alcohol
  homeostasis. Among the neurotransmitters which are suppressed/inhibited however, these include: Glutamate: By making this excitatory neurotransmitter less effective
  95 KB (11,688 words) - 02:47, 12 May 2024
• Selective serotonin reuptake inhibitor
  unknown. They are believed to increase the extracellular level of the neurotransmitter serotonin, eventually leading to improved mood.[citation needed][clarification
  15 KB (1,687 words) - 18:59, 22 November 2023
• Mephedrone
  is thought to produce its effects by promoting the release of the neurotransmitters serotonin, dopamine, and norepinephrine in the brain.[citation needed]
  29 KB (3,963 words) - 14:23, 16 April 2024
• Cocaine
  reuptake inhibition upon the neurotransmitters of serotonin and noradrenaline. It is this sudden flood of neurotransmitters that causes cocaine’s characteristic
  47 KB (6,322 words) - 08:08, 3 May 2024
• Tramadol
  Amphetamines - Stimulants facilitate the activity of the monoamine neurotransmitters, i.e., dopamine, norepinephrine and serotonin, in the central (CNS)
  22 KB (3,211 words) - 19:11, 7 April 2024
• 2-FEA
  primarily as a triple reuptake inhibitor, and that it releases the neurotransmitters: serotonin, dopamine, and norepinephrine. 2-FEA likely creates it effects
  13 KB (1,917 words) - 18:16, 30 April 2024
• Phenibut
  Phenibut acts as a receptor agonist for GABA, the major inhibitory neurotransmitter in the brain. It is chemically related to baclofen, pregabalin, and
  22 KB (2,703 words) - 18:36, 26 August 2023
• Phenethylamine (compound) (category Neurotransmitter)
  β-phenethylamine, or benzeneethanamine) is a trace amine and influencer of many neurotransmitters, such as dopamine and serotonin. Phenethylamine is an important molecule
  7 KB (919 words) - 17:25, 24 November 2023
• Harmala alkaloid
  inhibiting its endogenous function of destroying amine functions of neurotransmitters and externally administered centrally active drugs. This has the effect
  13 KB (1,772 words) - 02:21, 24 September 2023
• Methylone
  inhibitor/releasing agent of serotonin, norepinephrine, and dopamine. These neurotransmitters are thought to be responsible for regulating pleasure, motivation,
  19 KB (2,841 words) - 14:21, 16 April 2024
• F-Phenibut
  this site, F-Phenibut may reduce the release of several excitatory neurotransmitters, including glutamate, substance P, acetylcholine, and norepinephrine
  12 KB (1,795 words) - 20:04, 18 November 2023
• 3-FPM
  the synaptic clefts of neurons in the brain. This accumulation of neurotransmitters results in the experience of euphoric and stimulating effects. Its
  15 KB (2,265 words) - 06:42, 8 September 2023
• Diazepam
  Its mechanism of action is to increase the effects of the inhibitory neurotransmitter GABA. Diazepam was patented in 1955 by the pharmaceutical company Hoffman-La
  34 KB (4,165 words) - 14:05, 16 April 2024
• Scientific information (section Neurotransmitters)
  This section of PsychonautWiki is dedicated to providing the information necessary to understand the basic neuroscience and pharmacology involved in psychonautics
  599 bytes (162 words) - 23:00, 21 April 2024
• Psilocin
  is thought to emerge from the close chemical similarities with the neurotransmitter serotonin, which enables it to interact with a range of serotonin receptor
  40 KB (4,715 words) - 16:45, 25 January 2024
• Bufotenin
  elusive. Additional mechanisms of action such as reuptake inhibition of neurotransmitters such as serotonin, noradrenaline and dopamine are also thought to be
  16 KB (2,273 words) - 19:54, 7 April 2024
• Gabapentin
  substance of the gabapentinoid class. It is a structural analog of the neurotransmitter GABA and acts by inhibiting certain calcium channels in the brain,
  23 KB (2,828 words) - 23:50, 21 April 2024
• Lisdexamfetamine
  lisdexamfetamine produces its effects by promoting the release of neurotransmitters dopamine and norepinephrine in the brain. Subjective effects are essentially
  23 KB (3,617 words) - 09:16, 17 April 2024
• Caffeine
  Alongside this, caffeine also has effects on most of the other major neurotransmitters, including dopamine, acetylcholine, serotonin, and, in high doses,
  29 KB (3,603 words) - 00:00, 10 May 2024
• 2-Aminoindane
  it effectively boosts the levels of the norepinephrine and dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins
  12 KB (1,928 words) - 23:42, 21 April 2024
• DMT
  https://www.erowid.org/library/books_online/tihkal/tihkal06.shtml https://wiki.dmt-nexus.me/Ingestion_Methods https://www.erowid.org/plants/mimosa/mimosa_info2
  58 KB (7,681 words) - 22:15, 14 May 2024
• 3-MMC
  This means that it effectively boosts the levels of the monoamine neurotransmitters serotonin, norepinephrine, and dopamine in the brain by binding to
  18 KB (2,590 words) - 21:20, 30 April 2024
• 6-APDB
  inhibitor of the monoamine neurotransmitters known as serotonin, dopamine and noradrenaline which are the global neurotransmitters that modulate the brain's
  26 KB (4,015 words) - 23:44, 21 April 2024
• 3-FEA
  major monoamine neurotransmitters dopamine, norepinephrine, and serotonin in the brain by acting as a releasing agent of said neurotransmitters and/or by binding
  19 KB (3,317 words) - 15:23, 30 July 2022
• 2C-T
  MAOIs, stimulants and certain substances which promotes the release of neurotransmitters such as serotonin or dopamine. These substances include but are not
  13 KB (1,528 words) - 23:08, 29 May 2021
• 5-MAPB
  that 5-MAPB acts as a releasing agent for the previously mentioned neurotransmitters. As a result, releasing agents such as 5-MAPB may exert their activity
  13 KB (2,233 words) - 00:32, 31 December 2022
• Eszopiclone
  Eszopiclone is thought to increase the normal neurotransmission of the neurotransmitter GABA in the central nervous system in a similar yet distinct way to
  9 KB (1,257 words) - 18:31, 30 April 2024
• Ethylphenidate
  it effectively boosts the levels of the norepinephrine and dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins
  18 KB (2,561 words) - 14:02, 16 April 2024
• Dichloropane
  substance acts as a triple reuptake inhibitor and prevents monoamine neurotransmitters from being recycled, causing excessive amounts to build up in the synapse
  20 KB (2,747 words) - 00:19, 1 August 2022
• Theanine
  dextrorotary enantiomer. Theanine is structurally similar to the excitatory neurotransmitter glutamate, and in accordance, binds to glutamate receptors, though
  15 KB (1,935 words) - 23:24, 21 April 2024
• 5-APB
  previously mentioned neurotransmitters. This means it effectively boosts the levels of the serotonin, norepinephrine and dopamine neurotransmitters in the brain
  14 KB (2,336 words) - 23:43, 21 April 2024
• Prolintane
  dopamine results in higher concentrations of the two catecholamine neurotransmitters in the synaptic cleft, or gap between neurons. The result of this reduced
  11 KB (1,751 words) - 20:42, 12 September 2022
• Melatonin
  attached to an ethane chain. This monoamine chain can be found in many neurotransmitters, including histamine, dopamine, adrenaline, and noradrenaline. It is
  15 KB (1,896 words) - 23:12, 21 April 2024
• Main Page (section Please don't crawl the wiki. Use our API instead.PsychonautWiki ❤️ Developers. Please report any obstacles.)
  PsychonautWiki Indexes (Experience ⋅ Psychoactive substance ⋅ Psychonaut media ⋅ Replication ⋅ Subjective effect ⋅ Tripsitting ⋅ Tutorial) ⋅ Drug-related
  21 KB (1,004 words) - 23:38, 13 May 2024
• Choline bitartrate
  Choline is a chemical substance which serves as a precursor to the neurotransmitter acetylcholine in the brain. Choline is an essential nutrient in humans
  15 KB (1,961 words) - 23:23, 21 April 2024
• 4F-MPH
  meaning it effectively boosts the levels of dopamine and norepinephrine neurotransmitters in the brain by binding to and partially blocking the transporter proteins
  16 KB (2,465 words) - 15:45, 9 May 2024
• Piracetam
  at the alpha carbon. Piracetam shares structural similarity to the neurotransmitter GABA, its pyrrolidine core is the cyclic counterpart of GABA and could
  12 KB (1,475 words) - 00:39, 15 April 2023
• Ayahuasca
  with other MAOIs, stimulants and certain substances which releases neurotransmitters such as serotonin or dopamine. These substances include but are not
  33 KB (3,884 words) - 07:33, 16 November 2023
• NM-2-AI
  it effectively boosts the levels of the norepinephrine and dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins
  11 KB (1,914 words) - 23:46, 21 April 2024
• Isopropylphenidate
  it effectively boosts the levels of the norepinephrine and dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins
  19 KB (2,684 words) - 18:04, 30 July 2022
• Propylhexedrine
  monoamine neurotransmitters dopamine, norepinephrine, and serotonin (SNDRA), binding to and reversing their transporters, pumping these neurotransmitters from
  20 KB (2,813 words) - 21:23, 25 October 2023
• 2C-T-21
  with other MAOIs, stimulants and certain substances which releases neurotransmitters such as serotonin or dopamine. These substances include but are not
  18 KB (2,002 words) - 06:06, 12 August 2022
• 5-MeO-DMT
  elusive. Additional mechanisms of action such as reuptake inhibition of neurotransmitters such as serotonin, noradrenaline and dopamine are also thought to be
  26 KB (3,619 words) - 19:56, 7 April 2024
• 4F-EPH
  methylphenidate, meaning that it effectively boosts the levels of dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins
  17 KB (2,757 words) - 17:49, 30 July 2022
• 2C-T-7
  with other MAOIs, stimulants and certain substances which releases neurotransmitters such as serotonin or dopamine. These substances include but are not
  22 KB (2,709 words) - 23:09, 29 May 2021
• Methaqualone
  its receptor sites and magnifying the efficiency and effects of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors. As this
  12 KB (1,829 words) - 23:50, 21 April 2024
• Tyrosine
  boosts the levels of these neurotransmitters in the brain, resulting in stimulating and euphoric effects. These three neurotransmitters are collectively referred
  14 KB (2,109 words) - 23:22, 21 April 2024
• ETH-CAT
  result of this is an effective increase in the levels of catecholamine neurotransmitters like dopamine and norepinephrine in the brain by binding to and partially
  17 KB (2,584 words) - 12:23, 5 April 2024
• MDEA
  reuptake inhibitor of the monoamine neurotransmitters serotonin, dopamine and noradrenaline. These neurotransmitters are responsible for modulating focus
  25 KB (3,654 words) - 23:46, 21 April 2024
• 3,4-CTMP
  meaning it effectively boosts the levels of dopamine and norepinephrine neurotransmitters in the brain by binding to and partially blocking the transporter proteins
  24 KB (3,701 words) - 23:42, 21 April 2024
• Baclofen
  acting as an inhibitory ligand, inhibiting the release of excitatory neurotransmitters. Similarly to phenibut (β-phenyl-GABA), as well as pregabalin (β-isobutyl-GABA)
  16 KB (1,962 words) - 02:04, 19 March 2024
• Tianeptine
  thought to act immediately through the regulation of monoaminergic neurotransmitters (such as serotonin, dopamine, or noradrenaline.) Rather, it is theorized
  20 KB (2,399 words) - 00:17, 6 May 2024
• O-PCE
  subtype of receptors for glutamate, which are the principle excitatory neurotransmitters in the nervous system) allow for electrical signals to pass between
  16 KB (2,133 words) - 17:21, 17 March 2024
• Alprazolam
  benzodiazepine receptor site and magnifying the efficiency and effects of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors. Alprazolam
  25 KB (3,914 words) - 14:31, 16 April 2024
• 2-FA
  effectively increases the levels of the norepinephrine and dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins
  17 KB (3,024 words) - 17:25, 18 January 2024
• Butylone
  inhibitor/releasing agent of serotonin, norepinephrine, and dopamine. These are the neurotransmitters in charge of pleasure, reward, motivation and focus. This is done by
  18 KB (2,647 words) - 23:46, 21 April 2024
• Ethylone
  inhibitor/releasing agent of serotonin, norepinephrine, and dopamine. These are the neurotransmitters in charge of pleasure, reward, motivation and focus. This is done by
  17 KB (2,532 words) - 22:27, 31 July 2022
• 3-FA
  effectively increases the levels of the norepinephrine and dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins
  15 KB (2,726 words) - 11:39, 17 February 2024
• MDAI
  MDMA. This is done by inhibiting the reuptake and reabsorption of the neurotransmitters after they have performed their function of transmitting a neural impulse
  17 KB (2,560 words) - 07:40, 12 October 2023
• Theacrine
  theacrine is believed to have similar effects on most of the other major neurotransmitters, including dopamine, acetylcholine, serotonin, and, in high doses,
  10 KB (1,245 words) - 19:38, 30 April 2024
• Pentedrone
  shown to act as a pure reuptake inhibitor for the major catecholamine neurotransmitters dopamine and norepinephrine, with very modest activity on serotonin
  17 KB (2,503 words) - 00:26, 6 May 2024
• Lorazepam
  Scheduling, DEA | https://www.dea.gov/drug-information/drug-scheduling Polish wiki about controlled substances (no english translation)
  22 KB (2,595 words) - 13:26, 16 April 2024
• N-Ethylhexedrone
  monoamine reuptake transporters producing a decreased clearance of the neurotransmitters from the synapse. Furthermore, they may cause release of biogenic amines
  25 KB (3,455 words) - 23:45, 21 April 2024
• Flunitrazepam
  1269–1276. ISSN 0008-350X.  Flunitrazepam, 2022  Flunitrazepam - TripSit wiki  Robertson, M. D., Drummer, O. H. (May 1995). "Postmortem drug metabolism
  22 KB (2,689 words) - 20:55, 7 April 2024
• A-PHP
  may effectively boost the levels of the norepinephrine and dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins
  21 KB (3,212 words) - 09:58, 30 May 2023
• Hexedrone
  literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of
  8 KB (961 words) - 23:45, 21 April 2024
• MDA
  psychedelic MDA acts as a releasing agent and reuptake inhibitor of the neurotransmitters known as serotonin, dopamine and norepinephrine. It also functions
  31 KB (4,379 words) - 12:23, 6 May 2024
• Amanita muscaria
  it activates the receptor for GABA, the brain's principle inhibitory neurotransmitter. As an agonist, muscimol binds to the same site on the GABAA receptor
  16 KB (1,938 words) - 23:10, 21 April 2024
• A-PVP
  α-PVP does not act as a transporter substrate, i.e. it does not cause neurotransmitter release. It is a more potent inhibitor of DAT and NET than the classical
  24 KB (3,456 words) - 00:08, 3 November 2023
• Chlordiazepoxide
  Its mechanism of action is to increase the effects of the inhibitory neurotransmitter GABA. Chlordiazepoxide is notable among benzodiazepines for having
  15 KB (1,705 words) - 18:08, 14 January 2024
• Flurazepam
  drugs, characterized by their ability to enhance the effect of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain. It is chemically described
  2 KB (240 words) - 21:42, 5 May 2024
• Desoxypipradrol
  other stimulants. MAOIs - This combination may increase the amount of neurotransmitters such as dopamine to dangerous or even fatal levels. Examples include
  19 KB (2,776 words) - 00:39, 1 August 2022
• Methylnaphthidate
  effectively elevates the levels of dopamine, noradrenaline and serotonin neurotransmitters throughout the brain and CNS by binding to and partially blocking the
  9 KB (1,564 words) - 23:45, 21 April 2024
• ΑMT
  substance which act as a releasing agent or reuptake inhibitor of neurotransmitters such as serotonin and dopamine. Alcohol - aMT has a broad mechanism
  25 KB (2,825 words) - 16:14, 28 November 2022
• Methiopropamine
  increase this risk. MAOIs - This combination may increase the amount of neurotransmitters such as dopamine to dangerous or even fatal levels. Examples include
  13 KB (2,010 words) - 00:43, 1 August 2022
• Aniracetam
  subjective experiences. MAOIs - This combination may increase the amount of neurotransmitters such as serotonin and dopamine to dangerous or even fatal levels. Examples
  11 KB (1,427 words) - 22:01, 24 January 2024

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