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• Substituted tryptamines
  biologically important compounds such as hormones like melatonin and the neurotransmitter serotonin (5-hydroxytryptamine). Many psychoactive tryptamines have
  10 KB (461 words) - 23:05, 21 April 2024
• Cannabinoid
  chemical compounds that act on cannabinoid receptors on cells that alter neurotransmitter functioning in the brain. These receptor proteins include the endocannabinoids
  27 KB (3,598 words) - 22:59, 21 April 2024
• Main Page (section Please don't crawl the wiki. Use our API instead.PsychonautWiki ❤️ Developers. Please report any obstacles.)
  Adrenaline ⋅ Dopamine ⋅ GABA ⋅ Glutamate ⋅ Hormone ⋅ Melatonin ⋅ Neuron ⋅ Neurotransmitter ⋅ Noradrenaline ⋅ Receptor ⋅ Serotonin ⋅ Serotonin syndrome ⋅ Substance
  21 KB (1,004 words) - 23:38, 13 May 2024
• 4-FA
  info - Home  https://psychonautwiki.org/wiki/File:Behandeling-4-fa-intoxicatie.pdf https://psychonautwiki.org/wiki/File:4-FA%20risicobeoordeling%20(2016)
  21 KB (3,439 words) - 15:42, 30 July 2022
• Amphetamine
  this substantion. It can get up to around 2.5-3 points on the psychonaut wiki scale. (click Traces above to read more) Transformations - This effect occurs
  41 KB (5,610 words) - 19:01, 7 April 2024
• DMT
  as being a normal constituent of human metabolism and an endogenous neurotransmitter in certain rodents. Its presence is also known to be widespread throughout
  58 KB (7,681 words) - 22:15, 14 May 2024
• MDPV
  plays a role, although to a much lesser degree. This sudden increase in neurotransmitter concentration in the brain is thought to be responsible for the high
  23 KB (3,267 words) - 23:45, 21 April 2024
• Stimulants
  peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Cognitive fatigue Thought
  11 KB (1,055 words) - 02:52, 12 May 2024
• Methamphetamine
  peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Appetite suppression
  41 KB (5,798 words) - 13:29, 16 April 2024
• Lorazepam
  benzodiazepine receptor site and magnifying the efficiency and effects of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors. As this
  22 KB (2,595 words) - 13:26, 16 April 2024
• Molecular structure (section Neurotransmitters)
  In order to maintain consistency across the wiki, images of molecular structures should be produced in a standardized format rather than obtained from
  19 KB (857 words) - 09:55, 15 September 2022
• Antidepressants
  Antidepressants are thought to work by increasing levels of certain neurotransmitters, such as dopamine, serotonin, and/or norepinephrine in certain regions
  9 KB (1,069 words) - 21:47, 13 May 2024
• Dissociatives
  signals to pass, the NMDA receptor must be open. To remain open, the neurotransmitters known as glutamate and glycine must bind to the NMDA receptor. An NMDA
  12 KB (1,097 words) - 02:41, 12 May 2024
• Psychedelic
  means that they structurally mimic the endogenous neurotransmitter known as serotonin, the neurotransmitter that regulates higher-level brain functions such
  31 KB (3,363 words) - 22:58, 21 April 2024
• Nootropic
  altering the availability of the brain's supply of neurochemicals (i.e. neurotransmitters, enzymes, and hormones), by improving the brain's oxygen supply, or
  6 KB (658 words) - 23:00, 21 April 2024
• 4-FMA
  peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
  21 KB (3,467 words) - 16:14, 30 July 2022
• Etizolam
  GABA-A receptor complex, magnifying the efficicacy and effects of the neurotransmitter gamma aminobutyric acid (GABA) by increasing its ability to bind more
  30 KB (3,506 words) - 14:22, 16 April 2024
• Flunitrazepam
  benzodiazepine receptor site and magnifying the efficiency and effects of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors. As this
  22 KB (2,689 words) - 20:55, 7 April 2024
• Theobromine
  A1 and A2A receptors. During waking periods, the brain levels of the neurotransmitter adenosine steadily increase and trigger fatigue and sleepiness. The
  14 KB (1,908 words) - 08:31, 1 November 2023
• Adrenaline (category Neurotransmitter)
  Adrenaline (also known as epinephrine) is a hormone and neurotransmitter. It is primarily produced in the adrenal glands and certain neurons in humans
  5 KB (628 words) - 23:12, 21 April 2024
• 6-APB
  peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Appetite suppression
  33 KB (4,870 words) - 14:34, 16 April 2024
• MDMA
  often referred to as a "comedown" and is thought to occur because of neurotransmitter depletion. Although, it has been more and more commonly recognized
  85 KB (10,499 words) - 14:24, 16 April 2024
• GHB (category Neurotransmitter)
  acid and GHB) is a depressant substance. It is found naturally as a neurotransmitter and is also a precursor to GABA, glutamate, and glycine in certain
  35 KB (4,460 words) - 13:32, 16 April 2024
• Benzodiazepines
  by magnifying the efficiency and effects of the principal inhibitory neurotransmitter gamma-aminobutyric acid (GABA) by binding to and acting on its receptors
  28 KB (3,429 words) - 03:46, 9 May 2024
• Barbiturates
  doses, as agonists of GABAA receptors. GABA is the principal inhibitory neurotransmitter in the mammalian central nervous system (CNS). Barbiturates bind to
  16 KB (1,815 words) - 09:25, 14 January 2023
• Methylphenidate
  peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
  31 KB (4,254 words) - 15:15, 6 May 2024
• 2C-T-2 (category PsychonautWiki articles needing factual verification from October 2020)
  that 2C-T-2 is more likely to induce serotonin syndrome or general neurotransmitter overload (especially at high dosages) than other serotonergic psychedelics
  22 KB (2,627 words) - 23:08, 29 May 2021
• Alcohol
  homeostasis. Among the neurotransmitters which are suppressed/inhibited however, these include: Glutamate: By making this excitatory neurotransmitter less effective
  95 KB (11,688 words) - 02:47, 12 May 2024
• Selective serotonin reuptake inhibitor
  unknown. They are believed to increase the extracellular level of the neurotransmitter serotonin, eventually leading to improved mood.[citation needed][clarification
  15 KB (1,687 words) - 18:59, 22 November 2023
• Mephedrone
  peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
  29 KB (3,963 words) - 14:23, 16 April 2024
• Cocaine
  is often referred to as a comedown or “crash” and occurs because of neurotransmitter depletion. Many users report however that the severity of the “crash”
  47 KB (6,322 words) - 08:08, 3 May 2024
• Tramadol
  Haurand, M., Wilffert, B. (November 1996). "Influence of tramadol on neurotransmitter systems of the rat brain". Arzneimittel-Forschung. 46 (11): 1029–1036
  22 KB (3,211 words) - 19:11, 7 April 2024
• 2-FEA
  peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
  13 KB (1,917 words) - 18:16, 30 April 2024
• Phenibut
  Phenibut acts as a receptor agonist for GABA, the major inhibitory neurotransmitter in the brain. It is chemically related to baclofen, pregabalin, and
  22 KB (2,703 words) - 18:36, 26 August 2023
• Phenethylamine (compound) (category Neurotransmitter)
  functions as a monoaminergic neuromodulator and, to a lesser extent, a neurotransmitter in the human central nervous system. In addition to its presence in
  7 KB (919 words) - 17:25, 24 November 2023
• Harmala alkaloid
  inhibiting its endogenous function of destroying amine functions of neurotransmitters and externally administered centrally active drugs. This has the effect
  13 KB (1,772 words) - 02:21, 24 September 2023
• Methylone
  peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
  19 KB (2,841 words) - 14:21, 16 April 2024
• F-Phenibut
  and GABOB. It is a derivative of the naturally occurring inhibitory neurotransmitter γ-aminobutyric acid (GABA), with an addition of a phenyl ring that
  12 KB (1,795 words) - 20:04, 18 November 2023
• 3-FPM
  peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
  15 KB (2,265 words) - 06:42, 8 September 2023
• Diazepam
  Its mechanism of action is to increase the effects of the inhibitory neurotransmitter GABA. Diazepam was patented in 1955 by the pharmaceutical company Hoffman-La
  34 KB (4,165 words) - 14:05, 16 April 2024
• Scientific information (section Neurotransmitters)
  syndrome SSRI SNRI Synthetic cannabinoids Vagus nerve Hormone Neuron Neurotransmitter Monoamine Receptor Synapse Blood–brain barrier Serotonin Dopamine Glutamate
  599 bytes (162 words) - 23:00, 21 April 2024
• Psilocin
  is thought to emerge from the close chemical similarities with the neurotransmitter serotonin, which enables it to interact with a range of serotonin receptor
  40 KB (4,715 words) - 16:45, 25 January 2024
• Bufotenin
  elusive. Additional mechanisms of action such as reuptake inhibition of neurotransmitters such as serotonin, noradrenaline and dopamine are also thought to be
  16 KB (2,273 words) - 19:54, 7 April 2024
• Gabapentin
  substance of the gabapentinoid class. It is a structural analog of the neurotransmitter GABA and acts by inhibiting certain calcium channels in the brain,
  23 KB (2,828 words) - 23:50, 21 April 2024
• Lisdexamfetamine
  peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. The comedown produced by lisdexamfetamine, depending on
  23 KB (3,617 words) - 09:16, 17 April 2024
• Caffeine
  A1 and A2A receptors. During waking periods, the brain levels of the neurotransmitter adenosine steadily increase and trigger fatigue and sleepiness. The
  29 KB (3,603 words) - 00:00, 10 May 2024
• 2-Aminoindane
  peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
  12 KB (1,928 words) - 23:42, 21 April 2024
• 3-MMC
  peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
  18 KB (2,590 words) - 21:20, 30 April 2024
• 6-APDB
  peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Appetite suppression
  26 KB (4,015 words) - 23:44, 21 April 2024
• 3-FEA
  peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: Anxiety Cognitive fatigue
  19 KB (3,317 words) - 15:23, 30 July 2022

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