Search results

heavy. Responsible use Shulgin rating system Duration Routes of administration The Importance of Measured Doses (Erowid) Erowid Psychoactive Vaults : Dose 

which will calculate the amount of drug and solvent needed as well as the concentration. Main article: Routes of administration Oral cavity: Avoiding sublingual

conceptual thinking, euphoria, and depersonalization / dissociation. Routes of administration include oral, smoking, insufflation or injection. The effects are

that of 3-MeO-PCP but with a potentially higher risk of inducing states of mania, delusions and potential psychosis due to the greater degree of euphoric

variable in effect. (Description of distinguishing properties compared to other substances?) Its most common routes of administration include oral, sublingual

as a shorter duration. However, this route of administration is highly advised against due to the difficulties of measuring and handling substances that

dose-response curves. Responsible use Set and setting Dosage classification Routes of administration Trip sitter Dosage form (Wikipedia) American Weigh Scales, Inc

to the administration of DMT crystals): Rectal administration of DMT crystals (from 15 to 70 mg; from 4.5 to 7 hours) Sublingual administration of DMT crystal

based on the route of administration used. For example, it is especially present when smoked or vaporized, due to the relative abruptness of the substance

prescribed in the treatment of [https://en.wikipedia.org/wiki/Bipolar_disorder bipolar disorder. There is a large body of anecdotal evidence that suggests

the chances of syncope due to turbulent blood flow during valve operation. The rewarding mechanisms of cocaine are reversed by administration of amphetamine

as the use of soma in the origins of Hinduism, and many of these uses continue into the modern day. Some common examples of this are the use of wine containing

grinding of the teeth comparable to that of MDMA and traditional stimulants such as amphetamine. Perception of bodily lightness - In terms of the body’s

based on the route of administration used. For example, it is especially present when smoked or vaporized, due to the relative abruptness of the substance

be solely used for the purposes of scientific research. The use of research chemicals carries more risks than the use of more common, well-studied substances

Psychoactive class: Opioid/Stimulant Chemical class: Morphian Routes of Administration WARNING: Always start with lower doses due to differences between

(PsychonautWiki) | https://psychonautwiki.org/wiki/3-MeO-PCP#Toxicity_and_harm_potential PCP Psychosis (PsychonautWiki) | https://psychonautwiki.org/wiki/3-M

prescribed in the treatment of [https://en.wikipedia.org/wiki/Bipolar_disorder bipolar disorder. There is a large body of anecdotal evidence that suggests

the chances of syncope due to turbulent blood flow during valve operation. The rewarding mechanisms of cocaine are reversed by administration of amphetamine

the chances of syncope due to turbulent blood flow during valve operation. The rewarding mechanisms of cocaine are reversed by administration of amphetamine

than the rest of the 25x-NBOMe series with a total duration of 6 hours and a peak duration of 2 hours. It is moderately active at a dose of one milligram

Tutorial index List of reagent testing color charts (Wikipedia) Color Test Reagents/Kits for Preliminary Identification of Drugs of Abuse (Erowid) Ecstasy

the substance taken, dose and route of administration, the set and setting, the range of effects experienced, or the plots of any specific hallucinations

sublingually due to the high bioavailability of these routes. As with benzodiazepines, the sudden discontinuation of thienodiazepines can be dangerous or even

other classes of hallucinogen, this effect occurs more frequently than that of any other at moderate to heavy doses and is the defining feature of the experience

based on the route of administration used. For example, it is especially present when smoked or vaporized, due to the relative abruptness of the substance

molecule of the benzofuran class. The benzofuran class of substances are members of the amphetamine and phenylethylamine classes. Molecules of this class

the chances of syncope due to turbulent blood flow during valve operation. The rewarding mechanisms of cocaine are reversed by administration of amphetamine

carbon R4 of the phenyl ring. 2C-B belongs to the 2C family of phenethylamines, all of which possess methoxy groups on the 2 and 5 positions of the benzene

responsible context, the administration of repeated or high dosages of MDMA is most certainly neurotoxic in some form. Administration of MDMA causes subsequent

changes in the living human brain". Proceedings of the National Academy of Sciences of the United States of America. 92 (7): 2775–2779. ISSN 0027-8424.  http://www

incidents of psychological and physical harm have been attributed to the use of MDPV, including an unusually large number of fatalities. A total of 107 non-fatal

each day for a prolonged period of time instead of stopping abruptly. Flunitrazepam was discovered at Roche as part of the benzodiazepine work led by Leo

xanthine. Theobromine has an elimination half-life of 7.1±0.7 hours The principal mechanism of action of theobromine is as a nonselective antagonist at the

motivation enhancement, ego inflation, increased libido, and euphoria. Routes of administration include insufflation ("snorting" or "sniffing") and occasionally

conceptual thinking, euphoria, and depersonalization / dissociation. Routes of administration include oral, smoking, insufflation or injection. Rolicyclidine

often results in the loss of much of the final product. Dosage and preparation can be found in other parts of the psychonaut wiki. This is for informational

measuring the dose with the naked eye instead of a reliable milligram scale) and non-oral routes of administration. Volumetric liquid dosing is commonly recommended

stimulant-entactogen substance of the cathinone class. It is a structural analog of mephedrone (4-MMC). The mechanism of action is not fully studied, but

level trips. Perception of eternalism Perception of self-design Perception of predeterminism Perceived exposure to inner mechanics of consciousness Unity and

powdered form can be taken orally as well as via injection. Any other routes of administration other than oral are not recommended because diphenhydramine burns

analog of an ether analog of DOB, which would make it controlled under Buchstabe C. It could be considered an ether analog of an ether analog of para-bromoamphetamine

based on the route of administration used. For example, it is especially present when smoked or vaporized, due to the relative abruptness of the substance

approved by the Food and Drug Administration for the treatment of epilepsy disorders. The U.S. Drug Enforcement Administration has assigned Epidiolex a Schedule

psychedelic substance of the phenethylamine chemical class that produces psychedelic effects when administered. It is a member of the 2C-x family of psychedelic

the patients' perception of the world. A full reduction or disappearance of depersonalization occurred within the interval of 1–4 hours and, in some patients

Safer injection guide Sharing injection materials Responsible use Routes of administration North America Syringe Exchange Network Javed, Z; Burk, K; Facente

associated with the use of a synthetic cannabinoid product". Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology.

be capable of causing psychological dependence among users. Tolerance to many of the effects of omberacetam develops over several weeks of prolonged and

the chances of syncope due to turbulent blood flow during valve operation. The rewarding mechanisms of cocaine are reversed by administration of amphetamine

behavioral actions of this compound strongly suggest that the 5-HT2A receptor is an important site of action for DPT, but the modulatory actions of a 5-HT1A receptor

subjects after the administration of a single dose of methylphenidate and ethanol". Drug Metabolism and Disposition: The Biological Fate of Chemicals. 28 (6):

"Lack of effects of GHB precursors GBL and 1,4-BD following i.c.v. administration in rats: GBL and 1,4-BD after i.p. and i.c.v. administration". European

is a novel dissociative substance of the arylcyclohexylamine class. It is a structural analog of MXE. The mechanism of action is not known, but it is likely

(1996). "[Severe hyperthermia caused by sudden withdrawal of continuous intrathecal administration of baclofen]". Annales Francaises D’anesthesie Et De Reanimation

a quick onset of effects and rapid offset. There is little information available about the use of APICA via other routes of administration, although as

to the sedative-hypnotic effects develops within a couple of days of repeated administration. After that, it takes about 3 - 7 days for the tolerance to

symptoms of the lower urinary tract. A study conducted in 2015 demonstrated that co-administration of EGCG (10mM/kg) in rats receiving a daily dose of ketamine

trials involving the administration of 1000mg to 1600mg of modafinil per day for 7 to 21 consecutive days. Intentional acute overdoses of 4500mg and 4000mg

reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism. It is also worth noting

anecdotal reports of users experiencing painful chemical burns caused by ingesting pramiracetam powder sublingually. Other routes of administration do not seem

There is some evidence that suggests that co-administration of LSD with MDMA increases the neurotoxicity of the latter, and this may extend to 1cP-MiPLA

the blood level concentrations of the drug increases. Intravenous injection is the fastest route of drug administration, causing blood concentrations to

as if they are constantly on the verge of passing out instead of engaging in physical activities. This sense of sleep deprivation increases proportional

particular effect is uncommon during the first half of the trip but capable of manifesting itself towards the end of the experience, particularly if sleep deprivation

Loved"). It is a member of the 2C-x family of psychedelic phenethylamines, all of which were derived from the systematic modification of the mescaline molecule

subjects after the administration of a single dose of methylphenidate and ethanol". Drug Metabolism and Disposition: The Biological Fate of Chemicals. 28 (6):

intravenous administration of bufotenin results in excretion of (70%) of injected drug in the form of 5-HIAA, an endogenous metabolite of serotonin, while

contraction of groups of muscles), but is used off-label for other conditions. In the United States, it is not approved by the Food and Drug Administration for

reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism. It is also worth noting

structure of LSA contains a core structure of lysergic acid with an amine functional group bound to RN. The structure of lysergic acid is composed of a bicyclic

reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism. It is also worth noting

events induced by GHB administration. These findings may explain the paradoxical mix of sedative and stimulatory properties of GHB as well as the so-called

than that of clozapine. Other: The use of low doses of quetiapine for insomnia, while common, is not recommended; there is little evidence of benefit and

a psychedelic substance of the phenethylamine class. It is a member of the 2C-x family of psychedelic phenethylamines, all of which were derived from the

reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism. It is also worth noting

psychedelic substance of the phenethylamine chemical class that produces psychedelic effects when administered. It is a member of the 2C-x family of psychedelic

this substance to ensure the administration of the intended dose. As with other NMDA receptor antagonists, the chronic use of 3-MeO-PCMo can be considered

2-Aminoindane, is a structural analogue of amphetamine. It features the R3 terminal carbon of the propane chain of amphetamine bound to the benzene ring

in the context of social settings in which one is within the company of others, and only at lower, non-impairing doses. These feelings of sociability, affection

periods of time. It is highly recommended to taper one's dose by gradually lowering the amount taken each day for a prolonged period of time instead of stopping

lesser-known psychedelic substance of the phenethylamine class. It is a member of the 2C-x family of psychedelic phenethylamines, all of which are close relatives

binding than Buprenorphine, as well as being inactive through most routes of administration. Warning: Many psychoactive substances that are reasonably safe

substances ⋅ List of entheogens ⋅ List of pharmaceuticals ⋅ List of polysubstance combinations ⋅ List of precursors ⋅ List of prodrugs ⋅ List of psychoactive

them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the famous “k-hole.” Disclaimer:

Kingdom: 2-FEA is considered a Class A drug as a result of the amphetamine analogue clause of the Misuse of Drugs Act 1971. Responsible use Research chemical

grinding of the teeth comparable to that of MDMA and traditional stimulants such as amphetamine. Perception of bodily lightness - In terms of the body’s

smaller volume of water. The hydrochloride salt is soluble in three parts of water, whereas a gram of morphine hydrochloride dissolves in 16 ml of water; for

to shift the position of one's body and prolonged tensing of unusual combinations of muscle groups. Physical euphoria - Feelings of frequent but unpredictable

terminal amine RN of its tryptamine backbone (MET). 4-AcO-MET is an acetate ester analog of 4-HO-MET and the N-substituted ethyl homolog of 4-AcO-DMT. Further

reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism. It is also worth noting

by suppositories of ergotamine tartrate and caffeine (for the relief of migraine) and of chlorobutanol and caffeine (for the treatment of hyperemesis). However

(February 2016). "Pharmacokinetics of Memantine after a Single and Multiple Dose of Oral and Patch Administration in Rats". Basic & Clinical Pharmacology

disconnection of neurons leads to the general loss of bodily sensation, motor coordination, memory recall and eventually this substance's equivalent of the “k-hole

terminal amine RN of its tryptamine backbone. EPT is the N-ethyl analog of DPT and the N-propyl analog of DET. It is also an analog of 4-HO-EPT and 4-AcO-EPT

Francisco López-Munoz, the "discovery of haloperidol at the end of the 1950s constitutes one of the greatest advances of 20th century psychiatry." This antipsychotic

laboratory of David E. Nichols who prepared a series of mescaline analogues, including proscaline, jimscaline, isoproscaline, and others. The effects of escaline

reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism. It is also worth noting

Flurazepam belongs to the benzodiazepine class of drugs, characterized by their ability to enhance the effect of the neurotransmitter gamma-aminobutyric acid

psychedelic substance of the phenethylamine class that produces psychedelic effects when administered. It is a member of the 2C-x family of psychedelic phenethylamines

toxic dose of promethazine in humans (oral) is 3.5 mg/kg. This means that a person weighing 70 kg can show signs of toxicity at 245 mg. The LD50 of promethazine

substance of the phenethylamine class. It is a closely related analog of 25I-NBOMe and is reported to share most of its properties with the exception of a moderately

approximately 1% of the weight of Psilocybe cubensis mushrooms and so nearly 1.7 kilograms (3.7 lb) of dried mushrooms or 17 kilograms (37 lb) of fresh mushrooms

the chances of syncope due to turbulent blood flow during valve operation. The rewarding mechanisms of cocaine are reversed by administration of amphetamine

most potent routes of administration. Increased blood pressure - α-PHP, especially when it is vaporized or injected, can lead to sudden spikes of blood pressure

grinding of the teeth comparable to that of MDMA and traditional stimulants such as amphetamine. Perception of bodily lightness - In terms of the body’s

memebers of this class, it is speculated to exert its activity as some form of double or triple monoamine reuptake inhibitor. Like other members of the substituted

reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism. It is also worth noting

substance of the amphetamine class. It is a member of the DOx family of psychedelic amphetamines, which are known for their long duration and mixture of psychedelic

the chances of syncope due to turbulent blood flow during valve operation. The rewarding mechanisms of cocaine are reversed by administration of amphetamine

3-methyl-dihydromorphinone, is an opioid of the morphinan class. Hydrocodone and other molecules of this class contain a polycyclic core of three benzene rings fused

trials involving the administration of 1000mg to 1600mg of modafinil per day for 7 to 21 consecutive days. Intentional acute overdoses of 4500mg and 4000mg

most similar to that of mescaline among members of the 2C-x family, albeit with a significantly shorter duration. The synthesis of 2C-D was first published

lesser-known psychedelic substance of the amphetamine class. It is a member of the DOx family of psychedelic amphetamines. The synthesis of DOI was first described

and abuse potential of hexedrone. Due to its novelty and extremely short history of human usage, all information related to the use of this compound should

pharmacology of this substance, early reports indicate that vaporizing or freebasing the compounds shares most of the core components of the DMT experience

and a molecular weight of 237.29 g/mol. Allylescaline is known to have an average mass of 237.294998 Da and a monoisotopic mass of 237.136002 Da. Further

smokeless tobacco include: Mixed routes of administration: Kuber, a smokeless tobacco product known for its highly addictive properties and its unique presentation

the chances of syncope due to turbulent blood flow during valve operation. The rewarding mechanisms of cocaine are reversed by administration of amphetamine

Consolidated federal laws of Canada, Controlled Drugs and Substances Act  section 7c of chapter B of part A of the 1st appendix of the Dangerous Drugs Act

caustic to mucous membranes. Careless use may deteriorate the chosen routes of administration so it is important to practice routine maintenance such as soaking

toxicity of MiPT in humans, and it has little history of human usage. MiPT, or N-methyl-N-isopropyltryptamine, is a synthetic indole molecule of the tryptamine

Syntheses of various amide derivatives of norlysergic acid and related compounds. Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan, 96(5)

substance as it is covered by the phenethylamine derivatives clause of the Misuse of Drugs Act of 1971.[citation needed] United States: Proscaline is uncontrolled

novel stimulant substance of the cathinone class. N-Ethylhexedrone is a derivative of hexedrone and is part of a diverse group of compounds called the substituted

solution for deep subcutaneous and intra-muscular administration. As with codeine, intravenous administration should be avoided as it could result in anaphylaxis

(August 1983). "Some flavouring constituents of cassava and of processed cassava products". Journal of the Science of Food and Agriculture. 34 (8): 874–884.

dissociative substance that is found in the form of an inhalable gas. The exact mechanism of action of nitrous oxide is unknown, but it is thought to have

reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism. It is also worth noting

substance to ensure the accurate administration of the intended dose. As with other NMDA receptor antagonists, the chronic use of O-PCE can be considered moderately

Oxymorphone is an opioid of the morphinan class. Oxymorphone and other molecules of this class contain a polycyclic core of three benzene rings fused

(evident as psilacetin is also active via parenteral routes of ingestion). The psychedelic effects of 4-AcO-DMT are believed to come from its activity as

qualitative effects of 4-MeO-PCP which he said possessed 70% of the potency of PCP. 4-MeO-PCP was the first arylcyclohexylamine research chemical to be sold

reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism. It is also worth noting

analysis of the structure, it is presumed that THJ-018 has a similar binding profile to that of JWH-018 and matches many of the in vivo properties of Δ9-THC

Noorizadeh, M. (2012). "Application of GA–KPLS and L–M ANN calculations for the prediction of the capacity factor of hazardous psychoactive designer drugs"

usage. In rats, oral administration of dextromethorphan did not cause neurotoxic effects in laboratory tests. Oral administration of dextromethorphan repeatedly

while under the influence of Gaboxadol. Perception of bodily heaviness Stimulation - While most users report sedation and a lack of energy, some users also

them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually this substance's equivalent of the “K-hole.” Disclaimer:

reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism. It is also worth noting

potency of isopropylphenidate compared to methylphenidate is most significant with oral administration as the difference in potency is a result of the lower

ripples in the field of vision upon continuous administration. Within users who also regularly use psychedelics, it is capable of inducing these consistently

agent belonging to the racetam family of drugs. Although it is one of the first known and synthesized derivatives of piracetam, its research and efficacy

but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research

The GABAA receptor is made up of 5 subunits out of a possible 19, and GABAA receptors made up of different combinations of subunits have different properties

effects of ayahuasca alkaloids may be of relevance. Research on the antidepressant potential of psilocin suggests that the subjective effects of 5-HT2A

using this drug. In 2009, the U.S. Food and Drug Administration issued a warning of an increased risk of depression and suicidal thoughts and behaviors in

sudden, unexpected loss of consciousness along with a dangerous amount of depressed respiration. There is also an increased risk of suffocating on one's vomit

Non-oral routes also seem to exhibit a higher chance of overdosing, perhaps owing to differences in bioavailability, potency and unpredictability of dosage

reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism. It is also worth noting

There is some evidence that suggests that co-administration of LSD with MDMA increases the neurotoxicity of the latter, and this may extend to 1cP-AL-LAD

alkaloid of the lysergamide family. 1P-ETH-LAD is a structural analog of lysergic acid, with an N, N-diethylamide functional group bound to RN of the chemical

fast-paced in terms of the specific style of thought stream(s) produced and contains a large number of potential effects. The most prominent of these cognitive

unauthorized manufacture of the drug attracts a minimum sentence of 10 years of imprisonment and corporal punishment of five strokes of the cane, and a maximum

but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research

needed except in the case of severe psychotic episodes or the ingestion of fake acid (such as 25i-NBOMe or DOB). Administration of benzodiazepines or antipsychotics

terminal amine RN of its tryptamine backbone (MET). 4-HO-MET is a 4-hydroxy homolog of 4-AcO-MET and the N-substituted ethyl homolog of psilocin (4-HO-DMT)

the chances of syncope due to turbulent blood flow during valve operation. The rewarding mechanisms of cocaine are reversed by administration of amphetamine

published near the end of 2011 examined the effects of mephedrone in the brains of rats, as well as examining the reinforcing potential of mephedrone. Dopamine

pKa of 9.5 at 30 °C. Acetylcysteine serves as a prodrug to L-cysteine, a precursor to the biologic antioxidant glutathione. Hence administration of acetylcysteine

substance of the amphetamine class. DOM is a member of the DOx family of compounds which are known for their high potency, long duration, and mixture of psychedelic

needed except in the case of severe psychotic episodes or the ingestion of fake acid (such as 25i-NBOMe or DOB). Administration of benzodiazepines or antipsychotics

the chances of syncope due to turbulent blood flow during valve operation. The rewarding mechanisms of cocaine are reversed by administration of amphetamine

needed except in the case of severe psychotic episodes or the ingestion of fake acid (such as 25i-NBOMe or DOB). Administration of benzodiazepines or antipsychotics

Republic of China and Canada. For a period of time it was believed tramadol was not a purely synthetic drug after its apparent discovery in the roots of the

them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the famous “k-hole.” MXE

increase in these enzymes following administration of bromantane, and their upregulation causes a downstream increase in levels of dopamine, serotonin and epinephrine

pro-drug of choline (with the ability to influence both systemic and brain concentrations of choline). Due to the provision of the other half of the alpha-GPC

sensation of pain and results in an analgesic effect. Tapentadol also inhibits the reuptake of noradrenaline, which increases the levels of noradrenaline

effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics

history of human use, the toxicity and harm potential is not exactly known. Due to its similarity to MDMA, it is likely that the administration of repeated

as if they are constantly on the verge of passing out instead of engaging in physical activities. This sense of sleep deprivation increases proportional

There is some evidence that suggests that co-administration of LSD with MDMA increases the neurotoxicity of the latter, and this may extend to A and this

effects of TMA-6 are described as powerful mental stimulation along with undertones of intoxication that can increase the connectivity and rate of conceptual

systematic review of the effects of theanine and caffeine has confirmed that the combination seems to improve aspects of attention. The combination of L-theanine

consists of 5-15% essential oil by mass. 4-8.5% of nutmeg essential oil, or 0.2-1.3% of raw nutmeg, is myristicin. One study found 20 grams of nutmeg to

semi-synthethic alkaloid of the lysergamide famiy. It contains a core structure of lysergic acid with an amine functional group bound to RN of the chemical structure

reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism. It is also worth noting

effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics

lesser-known novel psychedelic substance of the tryptamine class. It is chemically related to psilocin and part of a series of substituted tryptamines that includes

magic of MDMA." The toxicity of methylone has not been well-studied, although it likely does not exceed that of MDMA, and it has a limited history of human

analog of DMT (Dimethyltryptamine). It is extremely uncommon and has little history of human usage. In the 1950s, the endogenous production of psychoactive

4-HO-DET is the lower homolog of 4-AcO-DET, the N-substituted diethyl homolog of 4-HO-DMT (psilocin) and the 4-hydroxy analog of DET. Further information:

from analysis of the structure, it is presumed that AB-FUBINACA has a similar binding profile to that of other cannabinoids and matches many of the in vivo

to carbon R4 of the phenyl ring. βk-2C-B belongs to the 2C family of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene

psychological study of marijuana intoxication. Marijuana (word), 2022  Definition of WEED  Definition of POT  Definition of GRASS  Definition of HEMP  Erowid

ripples in the field of vision upon continuous administration. Within users who also regularly use psychedelics, it is capable of inducing these consistently

for a prolonged period of time. For this reason, it is recommended to gradually lower the daily dose over a period of time instead of stopping abruptly —

Syntheses of various amide derivatives of norlysergic acid and related compounds. Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan, 96(5)

dihydrocodeine. The chemical structure of morphine is the basis of hundreds of opioid derivatives with a wide range of effects. Morphine exerts its effects

agent belonging to the racetam family of drugs. Although it is one of the first known and synthesized derivatives of piracetam, its research and efficacy

psychedelic substance of the tryptamine class that produces psilocybin-like psychedelic effects when administered. It is part of a series of psychedelic substituted

extremely difficult to stop its course because of the nature of absorption. Because of the extremely high strength of pure fentanyl powder, it is very difficult

this substance to ensure the administration of the intended dose. The oral LD50 (lethal dose in 50% of the population) of diazepam is 720 mg/kg in mice

well beyond the effective dose of .25 mg, and may increase instances of drowsiness the next day. Melatonin is comprised of a monoamine chain attached to

needed in the case of severe psychotic episodes or “fake acid” (a counterfeit substance such as 25x-NBOMe or DOx). Administration of benzodiazepines or

- All cannabinoids are capable of inducing paranoia at high doses, or with chronic administration, but the intensity of which can be considered much less

N-methylated derivative of 2-Aminoindane and is analogous to amphetamine. It features the R3 terminal carbon of the propane chain of amphetamine bound to

entheogenic purposes. It is an example of the early wave of psychedelic research chemical that were explored following the wake of its initial synthesis and documentation

range typical of creatine supplementation (in the range of 5g a day following an acute loading period) note increases to total body water of 6.2% (3.74lbs)

potency value of x10-12 of delorazepam which is roughly x10 the potency of diazepam. It should be noted that the sudden discontinuation of benzodiazepines

reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism. It is also worth noting

features of 2C-B, mescaline and MDA, with a duration of 6–8 hours (or up to 12 hours in larger doses). 2C-B-FLY is a derivative of the 2C-x family of psychedelic

choline uptake enhancer: (3) Mode of action of MKC-231 in the enhancement of high-affinity choline uptake. Journal of Neural Transmission, 115(7), 1037–1046

is a novel psychedelic substance of the lysergamide class. It is a structural analog of LSD and is part of a series of LSD analogs which includes AL-LAD

nootropic agent belonging to the racetam family of drugs. Although it is one of the first derivatives of piracetam to be synthesized and documented, research

many as one of euphoria and feelings of love or empathy. It contains a number of typical entactogenic cognitive effects. The most prominent of these cognitive

stimulating and fast-paced in terms of the specific style of thought stream(s) produced and contains a large number of potential effects. However, relative

mild stimulant equivalent to 100mg caffeine. In a study of fatigued volunteers the administration of 20mg or 40mg prolintane produced similar, but less intense

analysis of the structure, it is presumed that THJ-2201 has a similar binding profile to that of AM-2201 and matches many of the in vivo properties of Δ9-THC

psychedelic substance of the lysergamide class. It is one of the least known and least researched psychedelic substances. The pharmacology of LAE-32 is complex[citation

"Quantitative determination of the urinary excretion of ketobemidone and four of its metabolites after intravenous and oral administration in man". Drug Metabolism

a high therapeutic index, temazepam is one of the more dangerous of this class of drugs. The combination of alcohol or opioids and temazepam makes death

atom attached at R3 of the phenyl ring. Additionally, part of its amphetamine skeleton is incorporated into a morpholine ring. At R2 of its chain, an oxygen

molecule of the diarylethylamine class. The basic skeleton of diphenidine is a phenethylamine with a substituted Rα in phenyl ring. At the terminals of the

death of 50% of test animals) of acetylfentanyl and fentanyl are 9.3 mg/kg and 62 mg/kg, respectively. Significant bleeding in the small intestines of mice

effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics

equal to that of dextro-amphetamine. The duration of maximum activity spanned 180 minutes, and the total duration of excitation was in excess of 6 hours. Furthermore

period of cessation and relapse, largely because of reduced tolerance. To account for this lack of tolerance, it is safer to only dose a fraction of one's

It is one of the oldest known hallucinogens and the parent compound of the psychedelic phenethylamines, one of the two major subclasses of psychedelic

the R4 carbon of the phenyl ring, as well as a methyl substitution at RN. PMMA is the N-methylated version of PMA and the 4-Methoxy analog of Methamphetamine

and the Republic of the Congo, which uses the alkaloid-containing roots of the plant for its psychoactive properties in a number of ceremonies. Ibogaine

point of 149-153 °C. As with other salt forms, not all of the mass of a choline salt is choline. For choline bitartrate, 104.17/253.25 = 41.1% of its mass

sudden, unexpected loss of consciousness along with a dangerous amount of depressed respiration. There is also an increased risk of suffocating on one's vomit

initial trajectory of attack of an amine on a carbonyl group and was an important piece of experimental evidence for the proposal of the Bürgi–Dunitz angle

concentrations in the blood of 11 mg/L, liver of 24 mg/kg, kidney of 14 mg/kg, and brain of 8.9 mg/kg. As with other stimulants, the chronic use of ephedrine can be

hypnotic substance of the cyclopyrrolone class that is primarily used in the treatment of insomnia. Eszopiclone is known to belong to a family of drugs colloquially

can be thought of as the cathinone analog of ethylamphetamine given it has the same general formula, differing only by the addition of a single double-bonded

drug. 2mg of deschloroetizolam is thought to be of similar potency to 10mg of diazepam. Similar to benzodiazepines, the sudden discontinuation of thienodiazepines

reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism. It is also worth noting

all areas of the body. By inhibiting acetylcholinesterase, it increases the concentration and thereby action of acetylcholine in certain parts of the brain

the chances of syncope due to turbulent blood flow during valve operation. The rewarding mechanisms of cocaine are reversed by administration of amphetamine

bioavailability of about 90%. Peak plasma concentrations (Cmax) are reached eight to 12 hours after oral administration. It is one of the longest-acting

the chances of syncope due to turbulent blood flow during valve operation. The rewarding mechanisms of cocaine are reversed by administration of amphetamine

terms of its tolerance, desoxypipradrol can be used for multiple days in a row for extended periods of time. Acute tolerance to many of the effects of desoxypipradrol

Silverstone PH, Rue JE, Franklin M, et al. (September 1994). "The effects of administration of mCPP on psychological, cognitive, cardiovascular, hormonal and MHPG

reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism. It is also worth noting

toxic. Pethidine is a synthetic opioid of the phenylpiperidine class. Pethidine is the prototype of a large family of analgesics including the pethidine 4-phenylpiperidines

with genetic a family history of heart issues are discouraged from using this drug in its most potent methods of administration, if not avoid it entirely.

toxicity of ephenidine, and it has an extremely limited history of human usage. The abuse of diarylethylamines has been linked to a number of fatal and

physiological pH. The pK of midazolam is 6.15, which permits the preparations of salts to be water soluble. The parenteral solution of midazolam used clinically

reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism. It is also worth noting

for a prolonged period of time. For this reason, it is recommended to gradually lower the daily dose over a period of time instead of stopping abruptly —

as a full agonist of the GABAB receptor, similar to baclofen and high doses of GHB. At higher doses, phenibut loses its selectivity of GABAB, and gains

3-ethylmorphine, is an opioid of the morphinan class. Ethylmorphine and other molecules of this class contain a polycyclic core of three benzene rings fused

2/3rds the potency in terms of the stimulation it produces.[citation needed] The mechanisms of theacrine largely parallel those of caffeine in that while it

head space of zopiclone is described by many as one of intense sedation, decreased inhibition and severe amnesia. It produces a large number of cognitive

often results in states of hyper-focus in which one becomes fixated on a task for extended periods of time regardless of the purpose of it. Motivation enhancement

amount taken each day for a prolonged period of time instead of stopping abruptly. Flubromazolam is a chemical of the triazolobenzodiazepine (TBZD) class,

(November 2002). "Role of S-adenosyl-L-methionine in the treatment of depression: a review of the evidence". The American Journal of Clinical Nutrition. 76

milligrams of DXM with 300 milligrams of DPH, although some users prefer higher or lower amounts of either substance. This makes the spectrum of the combination

Review of Other Unexpected Clinical Effects of Zolpidem". Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep

central site of action, clonidine has been an important pharmacological tool in discovering the role of central α-adrenoceptors in the physiology of central

and stimulant substance of the cathinone class. It is the β-keto analog of MBDB and the substituted methylenedioxy analogue of buphedrone. As a designer

dosage. The general head space of ethylone is described by many as one of extreme mental stimulation, light feelings of love or empathy and moderate euphoria

Pain relief When a user of this substance keeps their eyes open throughout the duration of a moderate to strong trip, a number of open eye distortions and

benzene ring in place of the phenol ring found in tapentadol. The empirical formula of dextropropoxyphene is C22H29NO2 and has a molar mass of 339.471 grams per

others are members of the trimethoxylated family of phenethylamines. Members in this family been observed to produce a complex mixture of hallucinogenic,

when using this substance to ensure the accurate administration of the intended dose. The lethal dosage of metizolam has not been established; however, (like

only a small percentage of subjects noting presence of any side effects. Semax is a synthetic analogue of the short fragment of adrenocorticotropic hormone

resulting in extreme shaking of the entire body, unsteadiness of the hands, and a general lack of motor control. This style of stimulation is extremely similar

Huxley, author of Brave New World, became a user of psychedelics after moving to Hollywood. He was at the forefront of the counterculture's use of psychedelics

molecule of the substituted cathinone chemical class. Substituted cathinones refer to a class of molecules which are principally constituted of a phenethylamine

approximately 1% of the weight of Psilocybe cubensis and so nearly 1.7 kilograms (3.7 lb) of dried mushrooms or 17 kilograms (37 lb) of fresh mushrooms

properties, metabolism, and toxicity of methoxphenidine and it has an extremely limited history of human usage. A number of fatal and non-fatal overdoses have

Efavirenz is an inducer of the CYP2B6 and CYP3A4 enzymes of the cytochrome P450 system, and as a result may change the metabolism of drugs metabolized by

"Characterization of Flunitrazolam, a New Designer Benzodiazepine, in Oral Fluid After a Controlled Single Administration". Journal of Analytical Toxicology

physically safe to try in a responsible context, the administration of repeated or high dosages of MDEA is likely to be neurotoxic and cardiotoxic in some

sedating (or calming effects) of barbiturates on the nervous system. Pentobarbital has a bioavailability of 70-90%. 45-60% of pentobarbital will bind to proteins

from analysis of the structure, it is presumed that STS-135 has a similar binding profile to that of other cannabinoids and matches many of the in vivo properties

down. As of October 2, 2013, the justice ministry of Thailand suggested removal of kratom from the narcotic drug list relating to Category 5 of the Narcotic

as if they are constantly on the verge of passing out instead of engaging in physical activities. This sense of sleep deprivation increases proportional

reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism. It is also worth noting

but may not include all of them. Certain combinations may be safe in small doses of each but still, increase the potential risk of death. Independent research

from analysis of the structure, it is presumed that 5F-AKB48 has a similar binding profile to that of other cannabinoids and matches many of the in vivo

as if they are constantly on the verge of passing out instead of engaging in physical activities. This sense of sleep deprivation increases proportional

reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism. It is also worth noting

half-life of 2.5 hours. It attains steady-state concentration within 24-48 hours after administration The table below compares the selectivity of Tizanidine

and pharmacological examination of benzofuran, indan, and tetralin analogs of 3,4-(methylenedioxy)amphetamine". Journal of Medicinal Chemistry. 36 (23):

needed except in the case of severe psychotic episodes or the ingestion of fake acid (such as 25i-NBOMe or DOB). Administration of benzodiazepines or antipsychotics

methylene blue. The only consistently safe route of administration used with poppers is inhalation. Oral use of the liquid can prove fatal enough to result

synthetic tetrahedral molecule of the piperazino-azepine and phenethylamine group of compounds. It is comprised of a fusion of pyridine, benzene, azepine,

is an opioid substance of the phenylpropylamine class. It is an active metabolite of tramadol. O-DSMT has no documented history of human use before it appeared

Presse-Agentur, OTC availability of codeine products was rescinded nationwide in 2012 because of the discovery of the Krokodil method of underground desomorphine

post-synaptic effect of monoaminergic signaling at receptors on the receiving neuron. It is this sudden flood of neurotransmitters in the synapses of various brain

dosages of 150-450 mg/day, but conflicting results for the treatment of acute alcohol withdrawal. Two of the studies concerned the only maintenance of abstinence

Librium) is a depressant substance of the benzodiazepine class. Its mechanism of action is to increase the effects of the inhibitory neurotransmitter GABA

1967. In early 1968, the Bureau of Drug Abuse Control reported the seizure of over 1.4 kilograms of MDA and 11 kilograms of precursors from a clandestine

metabolism, and toxicity of NEP in humans. Due to its novelty and extremely short history of human usage, all information related to the use of this compound should

vodka-soaked tampons to get drunk. UserWiki:David Hedlund/Comparison of psychoactive alcohols in alcoholic drinks Risks of Combining Depressants - TripSit  https://www

The first official report of the drug came out of Finland in 2011 and another came from the UK in 2012. Pyrazolam is a drug of the benzodiazepine class

transferred by way of protein kinases. Phosphorylation of the hydroxyl group can change the activity of the target protein, or may form part of a signaling cascade

reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism. It is also worth noting

55%, 50% and 38% of cases reported for the first three quarters of 2017, respectively. Reports about the availability and effects of ephylone began to

Flualprazolam can be described as the 2'-fluoro derivative of alprazolam, or the fluoro instead of chloro analogue of triazolam, and has similar sedative and anxiolytic

effects. It has a unique and poorly-understood mechanism of action consisting of modulation of the brain's monoaminergic and glutamatergic systems. While

euphoriant of the cathinone chemical class with a potency of roughly 1/10th of that of mephedrone. This compound has little to no history of human usage

level of activity of certain Cytochrome P450 enzymes. Higher urinary pH elongates duration, while low urinary pH shortens duration. Higher activity of certain

reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism. It is also worth noting

infamous than some of its counterparts, misuse and recreational use of nitrazepam has been reported. It has been implicated in several cases of drug-facilitated

instability. The severity of symptoms is dictated by a number of factors, the most important of which is a degree of alcohol intake, length of time the individual

reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism. It is also worth noting

frequently use of cake can cause pancreas damage. Cake is almost illegal in all countries of the world. However there is one exception: Republic of Molossia

inner mechanics of consciousness Perception of eternalism Perception of interdependent opposites Perception of predeterminism Perception of self-design Spirituality

not only suitable for single administration during induction, but also for intraoperative maintenance. The site of action of intravenous anesthetics is generally

stimulating and sedating effects, depending on dosage and circumstances of consumption. The use of apomorphine carries risks, including potentially severe side effects

Substance(s): 4-HO-MPT Dose: around 120 mg Route of Administration: Oral Age: 21 Sex: M Height: 178 cm Weight: 60 kg Date: 09/2022 Misc: I take Venlafaxine

reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism. It is also worth noting

Substance(s): LSD Dose: Took 3.5 110μg blotters Route of Administration: Sublingual Sex: F Date: 28/07/2023 at 8:15pm For about a month now I have been

Substance(s): Ayahuasca • Dose: 50 g of Banisteriopsis caapi + 5 g of Mimosa tenuiflora • Route of Administration: brew • Age: 18 • Sex: male • Height:

Tulpas Oneirogens Responsible use Routes of administration Sensory deprivation Spokespeople Trip sitter PsychonautWiki High score board User levels Donate

dopamine receptors in various regions of the brain. By blocking the effects of dopamine, it helps alleviate symptoms of psychosis such as hallucinations, delusions

• Substance(s): DMT (changa) • Dose: 50 mg of DMT + 15 mg of harmala alkaloids • Route of Administration: vaporized • Age: 19 • Sex: male • Height: 175

derivative of lysergamide. It is chemically related to AL-LAD, with the "1D" prefix indicating a structural modification at the 1-position of the molecule

University of Cincinnati. In 1946, it became the first prescription antihistamine approved by the United States Food and Drug Administration (FDA). Diphenhydramine

started to contain remnants of a smell of rotten eggs, which I knew was characteristic of NAC. I noticed a general sense of reduced anxiety, which made

came across psychonaut wiki , searching all the posts about hundreds of different chemicals that I had been blissfully unaware of in the beginning. “dextro